Bad leases and landlords have put way more bookstores out of business than anything else. It's undoable for most, but the opposite end of the spectrum, stores who have bought their buildings have huge advantages. Strand and Powell's come to mind, but smaller, off the beaten path stores all over the country have done this and they never go away.
Regarding selling out of one's home, there should be an exception to the law for books, as there is (was?) for years at the post office and on the sidewalks of NYC. Yeah, that'll happen.